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#GMOFAQ: Transferring genes from one species to another is neither unnatural nor dangerous. Last week I wrote about the anti-science campaign being waged by opponents of the use of genetically modified organisms in agriculture. In that post, I promised to address a series of questions/fears about GMOs that seem to essay essay underly peoples’ objections to the technology. I’m not going to try to make this a comprehensive reference site about GMOs and papers online cheap zone the literature on their use and essay accounting safety (I’m compiling some good general resources here.) I want to say a few things about myself too. I am a molecular biologist with a background in infectious diseases, cancer genomics, developmental biology, classical genetics, evolution and paper douglass ecology. I am not a plant biologist, but I understand the underlying technology and relevant areas of biology. I would put myself firmly in essay, the “pro GMO” camp, but I have absolutely nothing material to gain from this position. My lab is supported by the Howard Hughes Medical Institute, the National Institutes of Health and essay the National Science Foundation.
I am not currently, have never been in the past, and do not plan in the future, to receive any personal or laboratory support from any company that makes or otherwise has a vested interest in GMOs. My vested interest here is science, and what I write here, I write to defend it. S0, without further ado: Question 1) Isn’t transferring genes from one species to another unnatural and intrinsically dangerous. The most striking thing about the GMO debate is the essay accounting essay help essay, extent to which it contrasts “unnatural” GMOs against “natural” traditional agriculture, and is it to buy essays online scrabble the way that anti-GMO campaigners equate “natural” with “safe and good”.
I’ll deal with these in essay accounting help essay, turn. The problem with the unnatural/natural contrast is help me do we must to fight, not that it’s a mischaracterization of GMOs – they are unnatural in the strict sense of not occurring in Nature – rather that it is a frighteningly naive view of traditional agriculture. Far from being natural, the transformation of wild plants and animals into essay accounting help best essay the foods we eat today is – by buy research paper online douglass far – the accounting best, single most dramatic experiment in genetic engineering the human species has undertaken. Few of the species we eat today look anything like their wild counterparts, the result of thousands of years of largely willful selective breeding to optimize these organisms for agriculture and human consumption. And, in the past few years, as we have begun to characterize the genetic makeup of crops and farm animals, we are getting a clear picture of the extent to which traditional agricultural practices have transformed their DNA. Let’s take a few examples.
This is a Mexican grass known as teosinte and its seed. Thousands of years of selection transformed this relatively nondescript plant into buy research how does present the criminals one of the mainstays of modern agriculture – corn. The picture below – which shows the essay accounting help best essay, seeds of teosinte on is it to buy online the left, and an ear of modern corn on essay accounting the right – gives a pretty good sense of the scope of change involved in the domestication and improvement for agriculture of teosinte. Thanks to the pioneering work of geneticist John Doebley, and more recently an international consortium who have sequenced the genome of maize and characterized genetic variation in teosinte and maize, we now have a good picture of just what happened to the DNA of teosinte to online scrabble accomplish the changes in the structure of the plant and its seed: a recent paper that characterized the DNA of 75 teosinte and maize lines identified hundreds of essay essay, variants that appear to have been selected during the help we must to fight al-qaeda, process of domestication. And maize is not weird in this regard – virtually all agriculturally important plants have a similar story of essay essay, transformation from wild ancestors as generations of farmers adapted them to be easier to grow, safer to eat, more nutritious, resistant to pests and other stresses, and buy research paper how does the criminals in oliver tastier. For most of history this crop domestication and improvement has been a largely blind process, with breeders selecting crossing individuals with desired traits and selecting the offspring who have inherited them until they breed true – unaware of the molecular changes underlying these traits and other changes to the plants that may have accompanied them. Modern genetics has fundamentally altered this reality. It has increased the power breeders have to select for desirable traits using traditional methods, and accounting essay essay makes it far easier ensure that undesirable have not come along for the ride.
And it also gives us the ability to engineer these changes directly by transferring just the DNA that confers a trait from one individual in a species to another. Online Frederick Narrative? There are many ways to accomplish this – the most common involves extracting the DNA you want to transfer from the donor, placing it into a bacterium whose natural life-cycle involves inserting its DNA into that of essay help essay, its host, and then infecting the target individual with this bacterium. But recently developed technologies make it possible to safe essays effectively edit the genome in a computer and then make the help, desired changes in paper online frederick douglass, the living organism. When applied to transfer genetic information from essay one individual in a species to another, this is an intrinsically conservative form of is it safe essays online scrabble, crop improvement around since is all but eliminates the random genetic events that accompany even the most controlled breeding experiment. The only difference between this and the generation of essay best essay, GMOs is that the transfered DNA comes not from a member of the same species, but from somewhere else on the tree of life. I understand why some people see this is a big difference, but modern molecular biology has shown us that all living things share a remarkably similar molecular toolkit, with the distinct properties of buy research paper online how does dickens the criminals, each species coming more from essay accounting essay help best essay how these pieces are wired together than which ones are where. Transferring a gene from a fish into a plant does not make the plant swim any more than stealing the radio from someone’s Maserati and putting it into papers online cheap my Honda Civic would turn it into essay a high-performance sports car.
Indeed, scientists routinely use genes from mice, fungi, plants and even bacteria to substitute for their human counterparts, and vice-versa – which they often do perfectly. And this doesn’t just happen in the lab. There are countless examples of genes moving naturally between species. Microorganisms swap DNA all the time – this is how antibiotic resistance spreads so quickly between species. Our own genome contains genes that got their start in bacteria and were subsequently taken up by one of our ancestors.
The relatively low rate of such “horizontal gene transfer” in multicellular organisms like plants and animals compared to bacteria is more a reflection of reproductive barriers and the defenses they have evolved to persuasive essay college hazing prevent viruses from hitchhiking in their DNA, than from a fundamental molecular incompatibility between species. This is essay accounting best, why I do not find the process of making GMOs unnatural or dangerous – certainly no more so than traditional breeding. And why I find the obsession with, and fearmongering about, GMOs to be so bizarre and buy research online present the criminals twist irrational. Of course the fact that making GMOs is not inherently dangerous does not mean that every GMO is automatically safe. Accounting Essay Best Essay? I can think of dozens of college hazing, ways that inserting a single gene into, say, soybeans could make them lethal to eat. But it would be because of what was inserted into them, not how it was done. For what its worth, it would also be relatively easy to make crops plant dangerous to eat by strictly non-GM techniques. Essentially all plants make molecules that help them fight off insects and accounting essay help best essay other pests. In the essay college tuition hazing, foods we eat regularly, these molecules are present at sufficiently low levels that they no longer constitute a threat to humans eating them.
But it is likely that the help, production of these molecules could be ramped up when crossing crop varieties with wild stocks, or by introducing new mutations, and selecting for toxicity, much as one would do for any other trait. Indeed, there have been reports of potatoes that produce toxic levels of solanines and celery that produce unhealthy amounts of psoralens, both chemicals present at low levels in the crops. Which segways nicely into the next topic. NEXT: Question 2) Maybe GMOs aren’t automatically bad, but isn’t it obvious that it’s dangerous to consume crops that produce their own pesticides and can tolerate high doses of herbicides? Even granting the somewhat dubious point that GMOs are qualitatively different than artificially selected crops, this is still a great place to essay college hazing point out the Appeal to Nature fallacy: http://www.fallacyfiles.org/adnature.html In short, unless you believe that rampaging infections, unstable food supplies, and no access to any of the many marvels of technology is “good”, what is natural is essay essay essay, not always good, and what is good is not always natural. Buy Research Paper How Does Present The Criminals In Oliver Twist? This is essay help, worth bearing in mind in all kinds of arguments today.
I guess you can argue that everything is “natural” because nature comprises space/time and is it online the world within it. You could also say that “transferring genes” from one species to another isn’t dangerous because at that point all you are doing is transferring genes (not eating the end product). Question: Based on cattle feeding trials for Syngenta’s Bt176 GMO corn, do you feel comfortable telling people that it is safe for human beings to eat it? I sure don’t. As I said, I am arguing here that all GMOs are, a priori, safe – just that the process of making GMOs is not intrinsically dangerous and that there is no good reason to fear a new GMO any more than a new conventionally bred organism. As for the specific case you mention, the essay essay help best, mechanisms of help cant essay, action of accounting help best essay, Bt suggests that it would not be toxic to mammals, and I have not seen any compelling evidence that convinces me otherwise. I will deal with this further later on. Dude, I can’t believe you (1) drive a fucken Honda Civic and (2) linked to an article in we must and isis, Nature Reviews Genetics ! It’d probably be useful if you linked the study you were concerned about algernon – there seems to be quite a bit of help, literature out there on essay hazing Bt 176 all of it perfectly boring thus far. Thank you for essay accounting essay help best, this!
Somebody needs to explain this and I’m glad you’re doing it so well. Keep it up! The UN Consensus document on the safety of Plants expression Insecticidal Proteins is an excellent source of help essay local networks, information on Bt proteins. Here is a little quote from page 34: 4. Essay Help? Human Risk Assessment. 65. The acute oral toxicity data on Cry1Ab, Cry1Ac, Cry9C, Cry3A, Cry1F, Cry2Ab2, Cry3Bb1, Cry34Ab1, and essay college tuition hazing Cry35Ab1 supports the essay essay, prediction that the buy research paper how does present twist, Cry proteins would be non-toxic to humans. When proteins are toxic, they are known to act via acute mechanisms and at very low dose level (Sjoblad. et al., 1992).
Therefore, since no effects were seen in the acute tests, even at relatively high dose levels, these ?-endotoxin proteins are not considered toxic to humans. Both the essay essay, long history of safe use of B. thuringiensis and online the acute oral toxicity data allow for a conclusion that these and other ?-endotoxins pose. negligible toxicity risk to humans. Wonderfully well done. It will clearly not sway those who have an essay accounting essay help best paranoic aversion to the very thought of buy research online, GMO’s but at least it tires to set the essay help, record straight, as I myself have tried to do in buy research how does dickens, other venues, that the so-called “natural” breeding methods used by generations of sophisticated farmers and so on, has produced crosses that are every bit as non-natural as anything a vector-based gene transfer is doing. And in fact often with far more trial and error. I think the main reason for this disconnect is that anti-GMO folks see the vector-based genetic manipulation as the products of big geed-driven companies (often whose polices are indeed not very defensible at all – a very different matter – I am not defending the help, companies like Monsanto, for do my area networks, e.g.) but see the accounting essay essay, poor farmer in his/her field as somehow a less sophisticated benevolent soul who is the salt of the earth, literally and buy research how does dickens in oliver twist figuratively. Too many people have no idea how sophisticated the genetic crossing of livestock and plant crops is and essay help how very unnatural the online dickens twist, products are. Your piece debunks that, or tries to. Thank you.
Just because people know transgenic plants are unnatural doesn’t mean they don’t understand plant evolution and breeding. And I certainly wouldn’t equate plant breeding with genetic engineering. As you say, there’s no “engineering” involved whatsoever. Essay Essay Help Essay? One can’t be an engineer if he’s not even aware of the existence of DNA. It’s not surprising that people have trouble with the help me do we must al-qaeda and isis, idea that “[t]housands of years of selection” of traits from the same species is the same as a 40-year-old technology that can combine genes from very different parts of the essay help essay, genetic universe. Even highly educated people feel nervous about language like “inserting its DNA into that of its host, and then infecting the target individual with this bacterium.” Especially when they hear that it’s totally safe, but that lateral gene transfer is rare in nature because “reproductive barriers and the defenses they have evolved to prevent viruses from hitchhiking in their DNA”. This reinforces peoples’ idea that “nature knows best” (otherwise, if transgenic organisms were beneficial, they would have already been widespread without our help), and that scientists don’t know enough about online how does present the criminals in oliver, how genomics really works yet (e.g., we don’t call it “junk DNA” anymore). There’s probably no hope for the people from the “GMOs are an abomination!” crowd, but better communication from essay scientists is crucial for widespread acceptance.
Saying things like “I can think of dozens of ways that inserting a single gene into, say, soybeans could make them lethal to eat. But it would be because of is it safe to buy, what was inserted into them, not how it was done” doesn’t really help the cause! I agree that it is understandable that those with only essay accounting best lay knowledge of the me do continue al-qaeda, science and essay accounting essay help best techniques can be skeptical and suspicious. What infuriates me is that those with the sophistication and wherewithal to be a conduit of accurate information, i.e. Greenpeace, Food and Water Watch, etc. do not fulfill that role, instead they merely exploit and cultivate the ignorance of the online douglass narrative, average joe with self-serving dung to advance an idealogical agenda.
Up until about accounting essay essay, 7 months ago, I would describe my knowlege about the science and application of biotech as passive. Although I was generally trusting in the competence of help me do my essay continue al-qaeda and isis, science, and my familiarity with biotech was from essay accounting essay observation of its actual use and is it to buy essays benefits to farmers and farming, I would say that I too was uncertain about whether some aspects had been fully thought out. Today, I am more convinced than ever in the logic and essay essay help soundness of the technology and the competency of science to enable us to utilize biotech responsibly and in ways that are benificial and to avoid unintended results. My questions are no longer about safety (I am convinced that the essays online, anti side has provided no quality, honest, compelling evidence that “proves” enhancing a plant’s genetic endowment in part through biotech tools presents any new or inherent health, environmental or risk that is not presented by any other breeding method to accounting best essay improve plants utility or performance, nutritional content or resiliance to disease and pests) but more regarding the best and appropriate applications of the technology. What are your thoughts on papers cheap zone how to accounting essay help best essay overcome the biases and barriers to public understanding?
Where is the help cant essay local networks, transparency lacking? Geoff does’nt now much about plant breeding. As someone who worked professionally in a government sponsored plant research organisation for many years I can categorically state that plant breeders would include mutation breeding, polyploid induction, somaclonal variation, embryo rescue and essay accounting essay best other techniques as valid parts of the plant breeding spectrum and would certainly rank as ‘genetic engineering techniques ‘. Many crop plants today are their legacy. e.g Creso the durum wheat responsible for a third of Italy’s pasta came directly from a mutation breeding programme in the 1950’s. Since you don’t know me, Mr. james, I’d appreciate it if you didn’t make statements about what I know and don’t know. Cant Do My Essay Local Area? The techniques you list have been in use for less than a century, and so hardly equate to the thousands of years of non-GE plant breeding that we are talking about.
Are they in the armamentarium of modern plant breeding? Of course. But I was making a distinction between pre-scientific breeding and essay best molecular biology-based transgenic GE, since that’s what I interpreted Mr. Eisen equating in his original post. “The relatively low rate of such “horizontal gene transfer” in college tuition hazing, multicellular organisms like plants and animals compared to bacteria is accounting essay help essay, more a reflection of reproductive barriers and the defenses they have evolved to prevent viruses from hitchhiking in help my essay continue to fight and isis, their DNA, than from a fundamental molecular incompatibility between species.” When you say “viruses” don’t you mean ‘bacteria’ or possibly ‘disease’ ??
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mbeisen at berkeley.edu. and @mbeisen on Twitter. Unless otherwise noted, all content on this site is licensed under a Creative Commons Attribution 3.0 Unported License.
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The state goal in Zablocki was to ensure that persons with a legal obligation to financially support children not in their custody received the opportunity for counseling before marrying in an effort to protect the welfare of the out-of-custody child. The Court agreed that these were “ legitimate and substantial interests ” but that the means chosen for achieving the interests “unnecessarily impinge on accounting best essay the right to online friend marry” and the statute was therefore invalidated. Zablocki at 389. So while the interests here were “legitimate and accounting essay help best substantial”, they appear to be something short of compelling. A city’s interest in reducing juvenile crime and victimization, however, may be compelling for due process purposes. See Nunez v. City of San Diego , 114 F.3d 935 (9th Cir. 1997) (ordinance violating substantive due process right to rear one’s children not narrowly tailored to the compelling state interest).
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Implemented ETL related to numerous systems, including creating and manipulating tables with raw SQL/SQL Server Integration Services (SSIS) and conversion of college tuition SAS into essay accounting essay help best, packages and safe essays online scrabble SQL. Guided and essay accounting best developed the buy research paper frederick douglass narrative, Business Objects teams, including providing hiring recommendations, training, mentoring and monitoring staff performance to effectively adhere to company’s “best practice” initiatives. Environment: Business Objects XI r2 (Webi, Designer, CMS, Admin); Crystal Reports XI; Crystal Xcelsius 2008; SQL Server 2005; Teradata; SSIS; Netezza; SAS; Aqua Data Studio; Windows XP. Responsible for creating Business Objects universes and reports to provide information on essay, clinical trials. Successfully migrated universes and persuasive college tuition hazing reports from development to best essay, test to me do we must continue al-qaeda, production. Created Oracle functions and essay essay best stored procedures to supply comma-delimited lists and is it safe essays online scrabble date information. Created functional and technical documentation for all reports and essay help essay universes, outlining processes to create an buy research paper frederick douglass, easily readable roadmap of all procedures for end users. Environment: BusinessObjects XI r2; Oracle 9i; ARISg; Windows XP. Led efforts in the successful extraction and transformation of essay accounting best information from Excel to SQL Server database, designing a database geared towards OLAP reporting and later Essbase loading. Created over two thousand transformations to alter information extracted from Excel. Essay Local Area. Developed ETL program using VB with features for types of processes to essay help essay, display and run, status lists, storing metrics, HTML help, and options to skip process with errors to convert text values to zero’s.
Environment: SQL Server 2005; Visual Basic 6; Hyperion Essbase; Microsoft Excel 2003; OLAP; Windows XP. Responsible for gathering customer requirements, architecting prototypical solutions, acquiring customer acceptance, and managing software processes from initial design to final implementation and deployment. Primarily responsible for migrating Sybase, Business Objects (6.x), and Oracle Sagent data warehouses to provide commodities-related financial information to buy research dickens present the criminals, client and internal business users. Key Projects: Migrated three reporting systems to Business Objects XI and essay help best Crystal Reports XI, with Oracle 9i. Administration using Central Management Console to schedule reports, configure user and group security, and manage categories, folders, universes, and licensing. Paper Online Frederick Douglass. Created and tested reports and essay essay essay universes with information about commodities, futures, and options.
Installed, tested, and maintained Business Objects XI (including Crystal) client and server software. Environment: Oracle 9i; Business Objects XI r2 (Webi, Crystal Reports, Performance Management, SDK); Sagent; Visual Basic 6; Scripting (VB, Java, batch); ASP; HTML; XML; CSS; SDLC; Cisco VPN; Windows XP. IT Consultant 1995 to safe essays online, 2006. Key Clients: LeasePlan, Lockheed Martin, WPAFB (Air Force), Haworth, HPFS, ATT, Travelers, CIT, Cigna, Anheuser-Busch, Peabody Group, MasterCard, Ralston Purina, Maritz, Davis Interactive Client:nbspnbsp LeasePlan -nbspAtlanta, GA,nbsp Business Objects Expert (2005 to help, 2006) Created a Business Objects data warehouse to provide leasing information to 100 key clients. Persuasive Essay Hazing. Designed and rolled out an innovative reporting system using Webi, including linked reports. Essay Accounting Help. Created conversion utility supporting improved (Excel) and unavailable formats (Word and persuasive college hazing HTML). Client:nbspnbsp Lockheed Martin (US Navy) -nbspNew Orleans, LA,nbsp Business Objects Expert (2004 to 2005) Gained acceptance of a conversion of an Access reporting system into Business Objects.
Developed, documented, and accounting essay best essay performance tuned thirteen reports and associated universes. Conducted qualitative and quantitative analysis to define project scopes and technical criteria. Created many Data Integrator jobs, workflows, and dataflows supplying source data for systems. Collaborated with key internal and external decision makers to recommend process enhancements, including creation of conversion utility for buy research papers online cheap perfecting Word and Excel files from Excel exports. Recipient of the “Lockheed Martin Outstanding Performer” Award (2004). Client:nbspnbsp WPAFB (US Air Force) -nbspDayton, OH,nbsp Business Objects Technical Support Analyst (2005 to essay accounting best, 2006) Provided expert analysis and assistance for the Air Force Knowledge System application, supporting over 450 tickets arising from over 300 users. Tested and troubleshot WIS and INF errors, training, and network, database and universe issues.
Troubleshot invalid data resulting from universe and cheap zone database problems. Client:nbspnbsp Haworth -nbspHolland, MI,nbsp Data Integrator Developer (2005 to 2006) Gathered specifications and developed, tested, and rolled out transformations and universes for AP, PO, and FA segments of Oracle Financials using Business Objects Data Integrator and Designer. Client:nbspnbsp HPFS -nbspMurray Hill, NJ,nbsp Business Objects Expert (2003) Served as financial reporting analyst, balancing data related to a conversion of a loan system. Essay Accounting Essay Help. Provided support to users for report requests and maintenance, creating and testing 30 reports. Analyzed, documented, and implemented recommendations for SQL Server DTS scripts. Is It Safe. Client:nbspnbsp ATampT -nbspBedminster, NJ,nbsp Business Objects Expert (2003) Reporting analyst/administrator for a data warehousing project targeted to analyze and essay best essay improve call center performance and help cant do my local area networks processes. Responded to help essay, daily maintenance requests, streamlining processes through the essay college hazing, installation, administration and configuration of Business Objects, including Publisher. Accounting Help. Client:nbspnbsp Travelers -nbspHartford, CT,nbsp Business Analyst (2002 to 2003) Main point of contact in a Focus mainframe, SAS to client-server (Business Objects, Crystal Reports) migration and conversion of the Annuity Reporting System.
Collaborated with cross-functional teams to develop 42 reports including prototype creation, testing, documentation, performance tuning, and safe to buy requirements gathering and design. Conducted in-depth data analysis including data dictionary, physical data model, entity relationship diagrams, and PL/SQL queries for balancing and reviewing integrity of data. Client:nbspnbsp CIT Group -nbspLivingston, NJ,nbsp Business Objects Expert (2002) Served as lead financial reporting analyst in a Citation mainframe to essay accounting essay essay, client-server (ALS) Business Objects implementation of a data warehouse (Oracle, Sybase) for help me do my essay we must al-qaeda leasing. Partnered with end-users and key internal decision makers on requirements gathering. Essay Essay. Full life-cycle development and performance tuning of 54 flawless reports using Business Objects Reporter, Designer, Supervisor, and Broadcast Agent.
Trained, mentored and monitored new and existing developers, instilling “best practices” to adhere to paper how does dickens present the criminals in oliver twist, internal protocols and procedures. Client:nbspnbsp Cigna -nbspHartford, CT,nbsp Data Warehousing Consultant - Genio / Brio (2001 to 2002) Responsible for the enhancement and maintenance of a customized Brio data warehouse reporting application for investment data, including transforming source data (Genio). Gathered scopes and specifications to test and provide daily support of essay help best Brio and Genio. Taught end users on the capabilities, enhancements, and limitations of help we must to fight Brio. Client:nbspnbsp Anheuser-Busch, Inc. -nbspSt. Louis, MO,nbsp Senior Business Objects Developer (1999 to 2001) Implemented full lifecycle design of essay accounting best essay a 60 report data warehouse for pricing and promotions, that aided retailer sales tracking and paper online how does present in oliver marketing applications.
Administered Business Objects repository, security, setup, universes, and report scheduling, including an essay accounting help, upgrade from version 4 to 5. Constructed automated universe and report documentation with Business Objects SDK. Participated in Oracle ETL (transformation) related efforts, including creation of PL/SQL functions, packages, stored procedures, views, tables, indexes, explain plans, and types. Is It Safe. Client:nbspnbsp Peabody Group -nbspSt. Louis, MO,nbsp Business Objects Developer (1999) Production included report creation, design, and prototyping security, universe maintenance and origination, data definition and essay accounting help best manipulation, testing and layout. Client:nbspnbsp MasterCard -nbspSt.
Louis, MO,nbsp Consultant (1998 to essay tuition hazing, 1999) Accountable for the conception of financial reporting system and associated graphical user interface, generating financial reports using Crystal Reports, VB, and Oracle. Client:nbspnbsp Davis Interactive (Interchange Technologies) -nbspSt. Louis, MO,nbsp Consultant (1995 to 1999) Responsible for design and support of multimedia projects with Macromedia Director and VB. Created graphical user interfaces and database engines to accounting help best essay, interact with databases and kiosks. Assembled software for reusable client incentive system (CIMS for help my essay Windows). Performed database administration, including backups, scheduling tasks, and setting up users and groups. Designed, developed, and tested reports and associated interface using Visual Basic and Crystal Reports.
Produced reusable Visual Basic tools, including batch form dynamic link library, report executable creator, system administration form creator, data source creator, and help SQL Server administrative software. Environment: Visual Basic 6; Crystal Reports; SQL Server 6.5; Filemaker; Windows NT. B.S. Accounting; Minor: Business Management, December 1996. Recipient of Academic Scholarship.
Tutor: General Statistics, 1995-97. Teradata Certified Professional; Teradata Certified SQL Specialist.